In a mass balance excretion trial in eight healthy male volunteers dosed to steady state with immediate-release viramune 200 mg given twice daily followed by a single 50 mg dose of 14 c-nevirapine, approximately 91.
Information about Viramune.
A dose increase for itraconazole should be considered when these two agents are administered concomitantly.
Boceprevir is partly metabolized by CYP3A4/5Co-administration of boceprevir with medicines that induce or inhibit CYP3A4/5 could increase or decrease exposurePlasma trough concentrations of boceprevir were decreased when administered with an NNRTI with a similar metabolic pathway as nevirapineThe clinical outcome of this observed reduction of boceprevir trough concentrations chewable viagra tablets. has not been directly assessed.
Coadministration of Viramune with elvitegravir in combination with cobicistat is not recommendedsee section 4.4
Serum levels of nevirapine can be reduced by concomitant use of the herbal preparation StJohn’s WortHypericum perforatumThis is due to induction of medicinal product metabolism enzymes and/or transport proteins by StJohn’s Wort.
If co-administered with Viramunean adjustment in the telaprevir dose should be considered.
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