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The effect of CYP3A4 and CYP2C19 inducerssuch as carbamazepinephenytoinrifampicin and StJohn’s worton cilostazol pharmacokinetics has not been evaluatedThe antiplatelet effect may theoretically be altered and should be carefully monitored when cilostazol is co-administered with CYP3A4 and CYP2C19 inducers.
The following adverse reactions are discussed in greater detail inother sections of the labeling:
Patients receiving treatment with cilostazol should continue with their life-style modificationssmoking cessation and exerciseand pharmacological interventionssuch as lipid lowering and antiplatelet treatmentto reduce the risk of cardiovascular eventsCilostazol is not a substitute for such treatments.
Advise the patient to read the FDA-approved patient labelingPatient Information)
Cilostazol treatment is contraindicated in patients receiving two or more additional antiplatelet/anticoagulant agentssee section 4.3
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