Comparison of colchicine, dapsone, triamcinolone, and diphenhydramine therapy for the treatment of brown recluse spider envenomation a double-blind, controlled study in a rabbit model.
Information about Colchicine.
Published reports on the pharmacokinetics of intravenous colchicine in patients with severe chronic liver diseaseas well as those with alcoholic or primary biliary cirrhosisand normal renal function suggest wide inter-patient variabilityIn some subjects with mild to moderate cirrhosisthe clearance of colchicine is significantly reduced and plasma half-life prolonged compared to healthy subjectsIn subjects with primary biliary cirrhosisno consistent trends were notedSee Hepatic ImpairmentNo pharmacokinetic data are available for patients with severe hepatic impairmentChild-Pugh C
Neuromuscular toxicity and rhabdomyolysis have been reported from chronic treatment with colchicine in therapeutic dosesespecially in combination with other drugs known to cause this effectPatients with impaired renal function and elderly patientseven those with normal renal and hepatic functionare at increased riskOnce colchicine treatment is ceasedthe symptoms generally resolve within 1 week to several months.
Gout is rare in pediatric patientsthe safety and effectiveness of colchicine capsules in pediatric patients has not been evaluated in controlled studies.
General information about the safe and effective use of colchicine capsules.
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