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ISOPTIN does not alter the normal atrial action potential or intraventricular conduction timebut depresses amplitudevelocity of depolarization and conduction in depressed atrial fibersISOPTIN may shorten the antegrade effective refractory period of accessory bypass tractsAcceleration of ventricular rate and/or ventricular fibrillation has been reported in patients with atrial flutter or atrial fibrillation and a coexisting accessory AV pathway following administration of verapamilsee WARNINGS
ISOPTIN regularly reduces the total systemic resistanceafterloadagainst which the heart works both at rest and at a given level of exercise by dilating peripheral arterioles.
Beta BlockersConcomitant therapy with beta-adrenergic blockers and verapamil may result in additive negative effects on heart rateatrioventricular conductionand/or cardiac buy feldene with paypal. contractilityThe combination of sustained-release verapamil and beta-adrenergic blocking agents has not been studiedHoweverthere have been reports of excessive bradycardia and AV blockincluding complete heart blockwhen the combination has been used for the treatment of hypertensionFor hypertensive patientsthe risks of combined therapy may outweigh the potential benefitsThe combination should be used only with caution and close monitoring.
This is not a complete list of possible side effectsIf you notice other effects not listed abovecontact your doctor or pharmacist.
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