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You must drink plenty of water to prevent additional clots while on warfarin coumadin.

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Bleeding gums blood in the urine bloody stools blurred vision burningcrawlingitchingnumbnesspricklingpins and needlesor tingling feelings chest pain or discomfort confusion coughing up blood difficulty with breathing or swallowing dizzinessfaintnessor lightheadedness when getting up suddenly from a lying or sitting position excessive bruising headache increased menstrual flow or vaginal bleeding nosebleeds paralysis peeling of the skin prolonged bleeding from cuts red or blacktarry stools red or dark brown urine stomach pain with cramping sweating unexplained swelling unusual tiredness or weakness.

Drugs may interact with COUMADIN through pharmacodynamic or pharmacokinetic mechanismsPharmacodynamic mechanisms for drug interactions with COUMADIN are synergismimpaired hemostasisreduced clotting factor synthesiscompetitive antagonismvitamin Kand alteration of the physiologic control loop for vitamin K metabolismhereditary resistancePharmacokinetic mechanisms for drug interactions with COUMADIN are mainly enzyme inductionenzyme inhibitionand reduced plasma protein bindingIt is important to note that some drugs may interact by more than one mechanismMore frequent INR monitoring should be performed when starting or stopping other drugsincluding botanicalsor when changing dosages of other drugsincluding drugs intended for short-term usee.gantibioticsantifungalscorticosteroidssee BOX WARNING

To make sure this medicine is safe for youtell your doctor if you have ever had:

Avoid making any changes in your diet without first talking to your doctorFoods that are high in vitamin Kliverleafy green vegetablesor vegetable oilscan make warfarin less effectiveIf these foods are part of your dieteat a consistent amount on a weekly basis.

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