Agents that modify 19 or inhibit 18 activation of astrocytes and microglia prevent the development of morphine tolerance; thus inhibition of gliosis by ultra-low dose naltrexone may prevent the development of analgesic tolerance.
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REVIA has fewif anyintrinsic actions besides its opioid blocking propertiesHoweverit does produce some pupillary constrictionby an unknown mechanism.
Safe use of REVIA in ultra rapid opiate detoxification programs has not been establishedsee ADVERSE REACTIONS
Some side effects can be seriousIf you experience any of these symptoms or those listed in the IMPORTANT WARNING sectioncall your doctor immediately:
In some individuals the use of opioid antagonists has been associated with a change in baseline levels of some hypothalamicpituitaryadrenalor gonadal hormonesThe clinical significance of such changes is not fully understood.
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