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, reserpine, mao inhibitors, clonidine may increase the risk of hypotension and or severe bradycardia.

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It is not known whether this medicine will harm an unborn babyTell your doctor if you are pregnant or plan to become pregnant while taking clonidine.

Tricyclic antidepressantsfor exampleamitriptylineElavilEndepimipramineTofranildesipramineNorpraminand clomipramineAnafranilcan block the blood pressure lowering effects of CatapresThis may cause blood pressure to rise.

There is no specific antidote for clonidine overdosageClonidine overdosage may result in the rapid development of CNS depressionthereforeinduction of vomiting with ipecac syrup is not recommendedGastric lavage may be indicated following recent and/or large ingestionsAdministration of activated charcoal and/or a cathartic may be beneficialSupportive care may include atropine sulfate for bradycardiaintravenous fluids and/or vasopressor agents for hypotension and vasodilators for hypertensionNaloxone may be a useful adjunct for the management of clonidine-induced respiratory depressionhypotension and/or comablood pressure should be monitored since the administration of naloxone has occasionally resulted in paradoxical hypertensionDialysis is not likely to significantly enhance the elimination of clonidine.

Restless leg syndromeRLSis a common cause for painful legs that typically eases with motionand becomes worse and more.

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