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Studies showed that diltiazem increased the AUC of midazolam and triazolam by 3-to 4-fold and the Cmax by 2-foldcompared to placeboThe elimination half-life of midazolam and triazolam also increased1.5-to 2.5-foldduring coadministration with diltiazemThese pharmacokinetic effects seen during diltiazem coadministration can result in increased clinical effectse.gprolonged sedationof both midazolam and triazolam.
If you are taking these medicines for anginado not suddenly stop taking them since this can cause severe angina for a day or two.
FDA pregnancy category CIt is not known whether diltiazem will harm an unborn babyTell your doctor if you are pregnant or plan to become pregnant while using this medication.
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