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PRECAUTIONS DEPO-MEDROL Sterile Aqueous Suspension exerts an inhibitory influence on the mechanisms and the tissue changes associated with inflammationVascular permeability is decreasedexudation diminishedand migration of the inflammatory cells markedly inhibitedIn additionsystemic manifestations such as fever and signs of toxemia may also be suppressedWhile certain aspects of this alteration of the inflammatory reaction may cicialis. be beneficialthe suppression of inflammation may mask the signs of infection and tend to facilitate spread of microorganismsHenceall patients receiving this drug should be watched for evidence of intercurrent infectionShould infection occurit must be brought under control by the use of appropriate antibacterial measuresor administration of this preparation should be discontinuedHoweverin infections characterized by overwhelming toxicitymethylprednisolone acetate therapy in conjunction with appropriate antibacterial therapy is effective in reducing mortality and morbidityWithout conjoint use of an antibiotic to which the invader-organism is sensitiveinjudicious use of the adrenal hormones in animals with infections can be hazardousAs with other corticoidscontinued or prolonged use is discouraged.
Musculoskeletal Conditions As with other adrenal steroidsDEPO-MEDROL Sterile Aqueous Suspension has been found useful in alleviating the pain and lameness associated with acute localized arthritic conditions and generalized arthritic conditionsIt has been used successfully to treat rheumatoid arthritistraumatic arthritisosteoarthritisperiostitistendinitissynovitistenosynovitisbursitisand myositis of horsestraumatic arthritisosteoarthritisand generalized arthritic conditions of dogsRemission of musculoskeletal conditions may be permanentor symptoms may recurdepending on the cause and extent of structural degeneration.
Potentiated by CYP3A4 inhibitorsegketoconazolemacrolidescyclosporineestrogensAntagonized by CYP3A4 inducersegbarbituratesphenytoincarbamazepinerifampincholestyramineMay potentiate cyclosporineseizure riskMay antagonize oral anticoagulantsmonitorisoniazidIncreased risk of arrhythmias with digitalisMay need to adjust dose of antidiabetic agentsMonitor for hypokalemia with potassium-depleting drugsegamphotericin BdiureticsConcomitant neuromuscular blocking agentsincreased risk of myopathyWithdraw anticholinesterase agents at least 24hrs before initiating corticosteroid therapyAminoglutethimide may lead to loss of corticosteroid-induced adrenal suppressionIncreased GI effects with aspirinother NSAIDsCaution with aspirin in hypoprothrombinemiaMay suppress reactions to skin tests.
The most commonly occurring side effects have included fluid retentionalteration in glucose toleranceincreased blood pressurebehavioral and mood changesincreased appetiteand weight gainthe incidence generally correlates with dosagetiming of administrationand duration of treatmentRef]
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